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PENGARUH KAYU MANIS (Cinnamonum cassia) YANG DIKONSUMSI SEBELUM ASUPAN GLUKOSA TERHADAP PERUBAHAN GLUKOSA DARAH POSTPRANDIAL

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ABSTRACT EFFECT OF CINNAM ON (Cinn a mo mu m c ass ia) CONSUMED BEFORE THE CHANGES OF GLUCOSE INTAKE POSTPRANDIAL BLOOD GLUCOSE Natrlia Indah Tampubolon NIM: 1041011 Cinnamon proven that it has potential to control blood glucose levels in individuals with diabetes mellitus. Cinnamon contains active compounds called poly phenols such as methyl hydroryl chalcone polymer or MHCP that trigger and wo*s synergistically with insulin cells and stimulate glucose uptake. This shows that MHCP is an effective insulin mimetic, Diabetes mellitus is a global problem which is a metabolic disease characterized ckonic increase in blood glucose levels due to impafed carbohydrate metabolism. This study was conducted to examine whether cinnamon which is consumed before glucose intake can affect postprandial blood glucose changes. This experimental study involvrng 30 zubjects of normoglycemia, with characteristic of age (20.2 r 1.7 years), weight (54.6 +9.1 kg), height (162.0 + 8.7 cm). Using the method of oral glucose tolerance test with glucose intake of 1.75 g/kg up to a maxrmum of 75 grams and 6 grams of cinnamon powder. Postprandial blood glucose was measured at time points 30, 60,90, and 120 minutes post-treament. AUC data for each group are: cinnamon control 30 nna, Q,534 + 229), 60 min (2,5 36 + 225), cn min (2,543 + l9l), and 120 min (2,581 + 230); 30 minule glucose control (4,103 + 564),60 min (4,706 +69q,cn min (4,170 + 714), and 120 min (3,735 + 730); treatment cinnamon glucose + 30 min (3,675 + 530), 60 nn (4,3M + 785), 90 min (3,731 + 606), and 120 min (3,349 + 536), calculated using the trapEzoidal rule forrnula. AUC compared to the control group to the treatment group using one-way ANNOVA statistical test and t-test. Comparison of total AUC glucose control group (17,262 + 1,927) and treatment group (15,592 + 1,891) showed a sipificant difference (p < .01). Results of analysis using cinnamon (6 grams), cinnamon in the control group did not affect fasting blood glucose, whereas in the treatment group showed that the intake of cinnamon before glumse intake affects the postprandial blood glucose changes. Keywords : cinnamon, hyperglycemia, normoglycemia, diabetes mellitus